Glycans and glycoconjugates

 

Glycans

Human milk oligosaccharides (HMOs)

Elling, L., Zervosen, A., Gutiérrez Gallego, R., Nieder, V., Malissard, M., Berger, E.G., Vliegenthart, J.F.G., Kamerling, J.P., 1999. UDP-N-acetyl-α-D-glucosamine as acceptor substrate of β-1,4-galactosyltransferase. Enzymatic synthesis of UDP-N-acetyllactosamine. Glycoconjugate J. 16, 327-336. https://doi.org/10.1023/A:1007039825505

Kamerke, C., Pattky, M., Huhn, C., Elling, L., 2012. Synthesis of UDP-activated Oligosaccharides with Commercial β-galactosidase from Bacillus circulans under Microwave Irradiation. J. Mol. Catal. B: Enzymatic 79, 27-34. https://doi.org/10.1016/j.molcatb.2012.04.003

Kamerke, C., Pattky, M., Huhn, C., Elling, L., 2013. Synthesis of Nucleotide-Activated Disaccharides with Recombinant β3-Galactosidase C from Bacillus circulans. J. Mol. Catal. B: Enzymatic 89, 73-81. https://doi.org/10.1016/j.molcatb.2012.12.014

Engels, L., Elling, L., 2014. WbgL: a novel bacterial α1,2-fucosyltransferase for the synthesis of 2′-fucosyllactose. Glycobiology 24, 170-178. https://doi.org/10.1093/glycob/cwt096

Fischöder, T., Cajic, S., Grote, V., Heinzler, R., Reichl, U., Franzreb, M., Rapp, E., Elling, L., 2019. Enzymatic Cascades for Tailored 13C6 and 15N Enriched Human Milk Oligosaccharides. Molecules 24, 3482. https://doi.org/10.3390/molecules24193482

Fischöder, T., Cajic, S., Reichl, U., Rapp, E., Elling, L., 2019. Enzymatic Cascade Synthesis Provides Novel Linear Human Milk Oligosaccharides as Reference Standards for xCGE-LIF Based High-Throughput Analysis. Biotechnol. J. 14, e1800305. https://doi.org/10.1002/biot.201800305

Glycoconjugates

Neo-glycoproteins